Long-Term Safety of Letrozole and Gonadotropin Stimulation for Fertility Preservation in Women With Breast Cancer.

ABSTRACT:

Context and objective

There has been increased attention to the issue of fertility preservation (FP). We aimed to investigate the long-term safety of FP via controlled ovarian stimulation with letrozole supplementation (COSTLES) prior to breast cancer treatment.

Design, setting, and participants

This is a prospective, nonrandomized, controlled study conducted between the years 2002 and 2014. A total of 337 women diagnosed with stage 3 or less invasive breast cancer were enrolled during a FP consultation before chemotherapy. Of those, 120 elected to undergo COSTLES for FP prior to chemotherapy (FP group). The remaining 217 patients did not undergo any FP procedure and served as the controls.

Main outcome measure

The primary end point was cancer recurrence defined as th

SUBMITTER: Kim J 

PROVIDER: S-EPMC4880171 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature