ST2L Transmembrane Receptor Expression: An Immunochemical Study on Endarterectomy Samples.

ABSTRACT:

Background

ST2 (suppression of tumorigenity) has been described as a receptor for the interleukin-33, a member of the IL-1 family of cytokines. It is associated to coronary artery disease, all-causes mortality and cardiovascular mortality.

Aims

The present study was designed to assess the immunohistochemical expression of the ST2 receptor (ST2L/Il-1R) in atherosclerotic plaques of formalin fixed paraffin-embedded internal carotid arteries of patients with and without cerebro-vascular symptoms.

Methods and results

The study involved 41 cases (23 asymptomatic and 18 symptomatic). All the clinical and morphological parameters examined were uniformly distributed between the two groups, with a mild predominance of degree of calcification in asymptomatic cases (p = 0.01). S

SUBMITTER: Marzullo A 

PROVIDER: S-EPMC4880330 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature