Heart Rate Variability and Incident Stroke: The Atherosclerosis Risk in Communities Study.

ABSTRACT:

Background and purpose

Low heart rate variability (HRV), a marker of cardiac autonomic dysfunction, has been associated with increased all-cause and cardiovascular mortality. We examined the association between reduced HRV and incident stroke in a community-based cohort.

Methods

The Atherosclerosis Risk in Communities (ARIC) study measured HRV using 2-minute ECG readings in 12 550 middle-aged adults at baseline (1987-1989). HRV indices were calculated using the SD of RR intervals (SDNN), the mean of all normal RR intervals (meanNN), the root mean square of successive differences of successive RR intervals (RMSSD), low (LF) and high (HF) frequency power, and the LF/HF ratio. All HRV measures were categorized into quintiles. Incident stroke was adjudicated through 2011. Cox re

SUBMITTER: Fyfe-Johnson AL 

PROVIDER: S-EPMC4880420 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature