Pattern Genes Suggest Functional Connectivity of Organs.

ABSTRACT: Human organ, as the basic structural and functional unit in human body, is made of a large community of different cell types that organically bound together. Each organ usually exerts highly specified physiological function; while several related organs work smartly together to perform complicated body functions. In this study, we present a computational effort to understand the roles of genes in building functional connection between organs. More specifically, we mined multiple transcriptome datasets sampled from 36 human organs and tissues, and quantitatively identified 3,149 genes whose expressions showed consensus modularly patterns: specific to one organ/tissue, selectively expressed in several functionally related tissues and ubiquitously expressed. These pattern genes imply intrinsi

SUBMITTER: Qin Y 

PROVIDER: S-EPMC4880915 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature