Design strategy of surface decoration for efficient delivery of nanoparticles by computer simulation.

ABSTRACT: Understanding the role of surface decoration of nanoparticles in protein adsorption and cellular uptake is of great importance in biomedicine. Here, by using dissipative particle dynamics simulations, we take two typical coating polymers (i.e., hydrophilic and zwitterionic polymers) as an example, and systematically investigate their effect on cellular delivery of hydrophobic and charged nanoparticles (in the presence of serum protein). Our results show that though two types of polymers are charge-neutral and can both reduce the protein adsorption, there exist some differences between their ability of protein resistance, especially in the case of positively charged nanoparticles. Besides, it is found that the coating polymers may also greatly decrease the cellular uptake efficiency of nano

SUBMITTER: Ding HM 

PROVIDER: S-EPMC4880933 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature