Rare intronic variants of TCF7L2 arising by selective sweeps in an indigenous population from Mexico.

ABSTRACT:

Background

Genetic variations of the TCF7L2 gene are associated with the development of Type 2 diabetes (T2D). The associated mutations have demonstrated an adaptive role in some human populations, but no studies have determined the impact of evolutionary forces on genetic diversity in indigenous populations from Mexico. Here, we sequenced and analyzed the variation of the TCF7L2 gene in three Amerindian populations and compared the results with whole-exon-sequencing of Mestizo populations from Sigma and the 1000 Genomes Project to assess the roles of selection and recombination in diversity.

Results

The diversity in the indigenous populations was biased to intronic regions. Most of the variation was low frequency. Only mutations rs77961654 and rs61724286 were located on exo

SUBMITTER: Acosta JL 

PROVIDER: S-EPMC4880969 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature