Lipid biomarkers and long-term risk of cancer in the Women's Health Study.

ABSTRACT:

Background

Lipid biomarkers, such as HDL-cholesterol concentrations, have been shown to have positive, inverse, and null associations with total, breast, and colorectal cancer risks. Studies of novel lipid biomarkers, such as apolipoprotein A-I (apo A-I) and apolipoprotein B-100 (apo B-100), and cancer risk have been sparse, to our knowledge.

Objectives

We evaluated the prospective association of total, breast, colorectal, and lung cancers and cancer mortality with circulating lipid biomarkers in 15,602 female health professionals in the Women's Health Study (aged ≥45 y, free of cardiovascular disease and cancer, and without hormone replacement therapy or lipid-lowering medications at baseline).

Design

Cox regression models estimated HRs of cancer endpoints (19 y medi

SUBMITTER: Chandler PD 

PROVIDER: S-EPMC4880994 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature