Elevations in serum anti-flagellin and anti-LPS Igs are related to growth faltering in young Tanzanian children.

ABSTRACT:

Background

Antibodies to LPS and flagellin have been described as indirect measures of increased gastrointestinal permeability and may be markers of environmental enteric dysfunction (EED), which is a condition associated with poor child growth.

Objective

We assessed whether LPS- and flagellin-specific immunoglobulin (Ig) concentrations were associated with poor growth in young Tanzanian children at risk of EED.

Design

Blood samples were obtained from 590 children at 6 wk, 6 mo, and 12 mo of age. Serum LPS- and flagellin-specific Ig concentrations (IgA and IgG) were measured with the use of an ELISA. Growth was measured on a monthly basis for 18 mo.

Results

Anti-LPS and anti-flagellin IgA and IgG concentrations increased over the first year of life and were hig

SUBMITTER: McDonald CM 

PROVIDER: S-EPMC4881001 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature