Neuron-Like Networks Between Ribosomal Proteins Within the Ribosome.

ABSTRACT: From brain to the World Wide Web, information-processing networks share common scale invariant properties. Here, we reveal the existence of neural-like networks at a molecular scale within the ribosome. We show that with their extensions, ribosomal proteins form complex assortative interaction networks through which they communicate through tiny interfaces. The analysis of the crystal structures of 50S eubacterial particles reveals that most of these interfaces involve key phylogenetically conserved residues. The systematic observation of interactions between basic and aromatic amino acids at the interfaces and along the extension provides new structural insights that may contribute to decipher the molecular mechanisms of signal transmission within or between the ribosomal proteins. Simila

SUBMITTER: Poirot O 

PROVIDER: S-EPMC4881015 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature