Disrupted axonal fiber connectivity in schizophrenia.

ABSTRACT:

Background

Schizophrenia is believed to result from abnormal functional integration of neural processes thought to arise from aberrant brain connectivity. However, evidence for anatomical dysconnectivity has been equivocal, and few studies have examined axonal fiber connectivity in schizophrenia at the level of whole-brain networks.

Methods

Cortico-cortical anatomical connectivity at the scale of axonal fiber bundles was modeled as a network. Eighty-two network nodes demarcated functionally specific cortical regions. Sixty-four direction diffusion tensor-imaging coupled with whole-brain tractography was performed to map the architecture via which network nodes were interconnected in each of 74 patients with schizophrenia and 32 age- and gender-matched control subjects. Testi

SUBMITTER: Zalesky A 

PROVIDER: S-EPMC4881385 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature