Identification of 42 Genes Linked to Stage II Colorectal Cancer Metastatic Relapse.

ABSTRACT: Colorectal cancer (CRC) is one of the leading causes of cancer mortality. Metastasis remains the primary cause of CRC death. Predicting the possibility of metastatic relapse in early-stage CRC is of paramount importance to target therapy for patients who really need it and spare those with low-potential of metastasis. Ninety-six stage II CRC cases were stratified using high-resolution array comparative genomic hybridization (aCGH) data based on a predictive survival algorithm and supervised clustering. All genes included within the resultant copy number aberrations were each interrogated independently at mRNA level using CRC expression datasets available from public repositories, which included 1820 colon cancers, and 167 normal colon tissues. Reduced mRNA expression driven by copy number

SUBMITTER: Al-Temaimi RA 

PROVIDER: S-EPMC4881437 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature