DNA Damage: A Main Determinant of Vascular Aging.

ABSTRACT: Vascular aging plays a central role in health problems and mortality in older people. Apart from the impact of several classical cardiovascular risk factors on the vasculature, chronological aging remains the single most important determinant of cardiovascular problems. The causative mechanisms by which chronological aging mediates its impact, independently from classical risk factors, remain to be elucidated. In recent years evidence has accumulated that unrepaired DNA damage may play an important role. Observations in animal models and in humans indicate that under conditions during which DNA damage accumulates in an accelerated rate, functional decline of the vasculature takes place in a similar but more rapid or more exaggerated way than occurs in the absence of such conditions. Also e

SUBMITTER: Bautista-Nino PK 

PROVIDER: S-EPMC4881569 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature