IgE Sensitization Profiles Differ between Adult Patients with Severe and Moderate Atopic Dermatitis.

ABSTRACT:

Background

Atopic dermatitis (AD) is a complex chronic inflammatory disease where allergens can act as specific triggering factors.

Aim

To characterize the specificities of IgE-reactivity in patients with AD to a broad panel of exogenous allergens including microbial and human antigens.

Methodology

Adult patients with AD were grouped according to the SCORAD index, into severe (n = 53) and moderate AD (n = 126). As controls 43 patients were included with seborrhoeic eczema and 97 individuals without history of allergy or skin diseases. Specific IgE reactivity was assessed in plasma using Phadiatop®, ImmunoCap™, micro-arrayed allergens, dot-blotted recombinant Malassezia sympodialis allergens, and immune-blotted microbial and human proteins.

Results

IgE reactivit

SUBMITTER: Mittermann I 

PROVIDER: S-EPMC4881900 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature