Animal Models of Rheumatoid Arthritis (I): Pristane-Induced Arthritis in the Rat.

ABSTRACT:

Background

To facilitate the development of therapies for rheumatoid arthritis (RA), the Innovative Medicines Initiative BTCure has combined the experience from several laboratories worldwide to establish a series of protocols for different animal models of arthritis that reflect the pathogenesis of RA. Here, we describe chronic pristane-induced arthritis (PIA) model in DA rats, and provide detailed instructions to set up and evaluate the model and for reporting data.

Methods

We optimized dose of pristane and immunization procedures and determined the effect of age, gender, and housing conditions. We further assessed cage-effects, reproducibility, and frequency of chronic arthritis, disease markers, and efficacy of standard and novel therapies.

Results

Out of 271 rats

SUBMITTER: Tuncel J 

PROVIDER: S-EPMC4881957 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature