Peptides in Bronchoalveolar Lavage in Chronic Obstructive Pulmonary Disease.

ABSTRACT:

Background

Chronic Obstructive Pulmonary Disease (COPD) is a heterogeneous disease with a significant public health burden. Currently there is no biomarker that identifies those at risk of developing COPD, progression of disease or disease phenotypes. We performed metabolomic profiling of bronchoalveolar lavage fluid (BALF) from COPD patients to determine if metabolites correlated with clinical measurements such as lung function, functional status and degree of emphysema.

Methods

Metabolomic components of BALF from 59 subjects with COPD and 20 healthy controls were separated by reversed-phase UPLC and analyzed by ESI-ToF mass spectrometry. We used univariate analysis and multiple regression models to investigate associations between metabolomic features and various clinical

SUBMITTER: Wendt CH 

PROVIDER: S-EPMC4881978 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature