Hemoporfin Photodynamic Therapy for Port-Wine Stain: A Randomized Controlled Trial.

ABSTRACT:

Background and objectives

Photodynamic therapy (PDT) has shown potentially beneficial results in treating port-wine stain, but its benefit-risk profile remains undefined. This study aimed to evaluate the efficacy and safety of PDT conducted with hemoporfin and a 532 nm continuous wave laser to treat port-wine stain clinically.

Patients and methods

This randomized clinical trial was conducted in eight hospitals in China. Participants were adolescent and adult patients (age range: 14-65 years old) with port-wine stain. During stage 1 (day 1 to week 8) all patients were randomized at a 3:1 ratio to treatment (532 nm laser irradiation (96-120 J/cm2) with hemoporfin (5mg/kg; PDT-hemoporfin, n = 330)) or placebo groups (irradiation with placebo (PDT-placebo, n = 110)); during stag

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC4881994 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature