Association Between Accelerated Multimorbidity and Age-Related Cognitive Decline in Older Baltimore Longitudinal Study of Aging Participants without Dementia.

ABSTRACT:

Objectives

To explore the association between rate of physical health deterioration, operationalized as rising multimorbidity overtime, and longitudinal decline in cognitive function in older adults without dementia.

Design

Longitudinal (Baltimore Longitudinal Study of Aging (BLSA)).

Setting

Community.

Participants

BLSA participants aged 65 and older followed for an average of 3 years and free of dementia or mild cognitive impairment (MCI) at baseline and follow-up (N = 756).

Measurements

Standardized neurocognitive tests evaluating mental status, memory, executive function, processing speed, and verbal fluency were administered. Multimorbidity was assessed at each visit as number of diagnosed chronic diseases from a predefined list. Faster accumulation

SUBMITTER: Fabbri E 

PROVIDER: S-EPMC4882249 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature