Proinflammatory and lipid biomarkers mediate metabolically healthy obesity: A proteomics study.

ABSTRACT:

Objective

The metabolically healthy obesity (MHO) phenotype is an important obesity subtype in which obesity is not accompanied by any metabolic comorbidity. However, the underlying molecular mechanisms remain elusive. In this study, a shotgun proteomics approach to identify circulating biomolecules and pathways associated with MHO was used.

Methods

The subjects were 20 African-American women: 10 MHO cases and 10 metabolically abnormal individuals with obesity (MAO) controls. Serum proteins were detected and quantified using label-free proteomics. Differential expression of proteins between the two groups was analyzed, and the list of differentially expressed proteins was analyzed to determine enriched biological pathways.

Results

Twenty proteins were differentially e

SUBMITTER: Doumatey AP 

PROVIDER: S-EPMC4882259 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature