Renal Function in Nucleos(t)ide Analog-Treated Patients With Chronic Hepatitis B: A Systematic Literature Review and Network Meta-Analysis.

ABSTRACT:

Introduction

Renal safety is an important factor in selecting the most appropriate nucleos(t)ide analog (NA) treatment for patients with chronic hepatitis B (CHB). This systematic literature review and network meta-analysis aimed to assess renal function associated with telbivudine treatment compared to other NAs in patients with CHB.

Methods

A systematic literature search via Medline, Medline In-Process, Embase, and the Cochrane library for publications of randomized controlled trials and observational studies was conducted. Network meta-analysis was performed to compare renal function with telbivudine treatment versus other NAs after 1 year of therapy.

Results

Overall, 40 (six randomized controlled and 34 observational) studies were included for review. Telbivudine

SUBMITTER: Chan HL 

PROVIDER: S-EPMC4882346 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature