Inorganic Phosphate Limitation Modulates Capsular Polysaccharide Composition in Mycobacteria.

ABSTRACT: Mycobacterium tuberculosis is protected by an unusual and highly impermeable cell envelope that is critically important for the successful colonization of the host. The outermost surface of this cell envelope is formed by capsular polysaccharides that play an important role in modulating the initial interactions once the bacillus enters the body. Although the bioenzymatic steps involved in the production of the capsular polysaccharides are emerging, information regarding the ability of the bacterium to modulate the composition of the capsule is still unknown. Here, we study the mechanisms involved in regulation of mycobacterial capsule biosynthesis using a high throughput screen for gene products involved in capsular α-glucan production. Utilizing this approach we identified a group of mut

SUBMITTER: van de Weerd R 

PROVIDER: S-EPMC4882446 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature