Pancreatic polypeptide and its central Y4 receptors are essential for cued fear extinction and permanent suppression of fear.

ABSTRACT:

Background and purpose

Avoiding danger and finding food are closely related behaviours that are essential for surviving in a natural environment. Growing evidence supports an important role of gut-brain peptides in modulating energy homeostasis and emotional-affective behaviour. For instance, postprandial release of pancreatic polypeptide (PP) reduced food intake and altered stress-induced motor activity and anxiety by activating central Y4 receptors.

Experimental approach

We characterized [K(30) (PEG2)]hPP2-36 as long-acting Y4 receptor agonist and injected it peripherally into wildtype and Y4 receptor knockout (Y4KO) C57Bl/6NCrl mice to investigate the role of Y4 receptors in fear conditioning. Extinction and relapse after extinction was measured by spontaneous recovery an

SUBMITTER: Verma D 

PROVIDER: S-EPMC4882497 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature