Quercetin Impacts Expression of Metabolism- and Obesity-Associated Genes in SGBS Adipocytes.

ABSTRACT: Obesity is characterized by the rapid expansion of visceral adipose tissue, resulting in a hypoxic environment in adipose tissue which leads to a profound change of gene expression in adipocytes. As a consequence, there is a dysregulation of metabolism and adipokine secretion in adipose tissue leading to the development of systemic inflammation and finally resulting in the onset of metabolic diseases. The flavonoid quercetin as well as other secondary plant metabolites also referred to as phytochemicals have anti-oxidant, anti-inflammatory, and anti-diabetic effects known to be protective in view of obesity-related-diseases. Nevertheless, its underlying molecular mechanism is still obscure and thus the focus of this study was to explore the influence of quercetin on human SGBS (Simpson Gol

SUBMITTER: Leiherer A 

PROVIDER: S-EPMC4882695 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature