Baseline frontostriatal-limbic connectivity predicts reward-based memory formation.

ABSTRACT: Reward mediates the acquisition and long-term retention of procedural skills in humans. Yet, learning under rewarded conditions is highly variable across individuals and the mechanisms that determine interindividual variability in rewarded learning are not known. We postulated that baseline functional connectivity in a large-scale frontostriatal-limbic network could predict subsequent interindividual variability in rewarded learning. Resting-state functional MRI was acquired in two groups of subjects (n = 30) who then trained on a visuomotor procedural learning task with or without reward feedback. We then tested whether baseline functional connectivity within the frontostriatal-limbic network predicted memory strength measured immediately, 24 h and 1 month after training in both groups. W

SUBMITTER: Hamann JM 

PROVIDER: S-EPMC4883096 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature