Effect of varenicline on smoking cessation through smoking reduction: a randomized clinical trial.

ABSTRACT:

Importance

Some cigarette smokers may not be ready to quit immediately but may be willing to reduce cigarette consumption with the goal of quitting.

Objective

To determine the efficacy and safety of varenicline for increasing smoking abstinence rates through smoking reduction.

Design, setting, and participants

Randomized, double-blind, placebo-controlled, multinational clinical trial with a 24-week treatment period and 28-week follow-up conducted between July 2011 and July 2013 at 61 centers in 10 countries. The 1510 participants were cigarette smokers who were not willing or able to quit smoking within the next month but willing to reduce smoking and make a quit attempt within the next 3 months. Participants were recruited through advertising.

Interventions

Tw

SUBMITTER: Ebbert JO 

PROVIDER: S-EPMC4883651 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature