Comparative Analysis of Gut Microbiota of Native Tibetan and Han Populations Living at Different Altitudes.

ABSTRACT: The factors driving the composition of gut microbiota are still only partly understood but appear to include environmental, cultural, and genetic factors. In order to obtain more insight into the relative importance of these factors, we analyzed the microbiome composition in subjects of Tibetan or Han descent living at different altitudes. DNA was isolated from stool samples. Using polymerase chain reaction methodology, the 16S rRNA V1-V3 regions were amplified and the sequence information was analyzed by principal coordinates analysis and Lefse analyses. Contrasting the Tibetan and Han populations both living at the 3600 m altitude, we found that the Tibetan microbiome is characterized by a relative abundance of Prevotella whereas the Han stool was enriched in Bacteroides. Comparing the m

SUBMITTER: Li K 

PROVIDER: S-EPMC4883765 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature