Immuno-PET of epithelial ovarian cancer: harnessing the potential of CA125 for non-invasive imaging.

ABSTRACT:

Background

Epithelial ovarian cancer (EOC) is characterized by the overexpression of cancer antigen 125 (CA125), a mucinous glycoprotein that serves as a tumor biomarker. Early diagnosis of EOC is plagued by its asymptomatic nature of progression and the limitations of currently used immunoassay techniques that detect CA125 as a shed antigen in serum samples. Presently, there is no technique available for the in vivo evaluation of CA125 expression in malignant tissues. Moreover, there could be an unexplored pathophysiological time window for the detection of CA125 in EOC, during which it is expressed on tumor cells prior to being shed into the bloodstream. A method for the in vivo evaluation of CA125 expression on ovarian neoplasms earlier along disease progression and/or recurrenc

SUBMITTER: Sharma SK 

PROVIDER: S-EPMC4883985 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature