Generation of transgenic rice with reduced content of major and novel high molecular weight allergens.

ABSTRACT:

Background

Rice seed proteins contain antigens that provoke allergic responses in some individuals with food allergy, particularly in those with cereal allergy, and these antigens can elicit clinical symptoms such as eczema and dermatitis. We previously generated transgenic rice with reduced accumulation of the three major allergens, which dramatically reduced the level of IgE binding from patients' sera. However, the transgenic rice still possesses allergenic reactivity. Recently, two globulin-like proteins were identified as candidates of novel high molecular weight (HMW) IgE-binding proteins that cause rice allergy.

Results

We identified a glucosidase family encoded by four genes as novel HMW rice allergens based on IgE antibody reactivity from individuals with allergy to

SUBMITTER: Ogo Y 

PROVIDER: S-EPMC4884044 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature