Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.

ABSTRACT: Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet been studied with genome-wide data. We conducted genome-wide association studies of three phenotypes: subjective well-being (n = 298,420), depressive symptoms (n = 161,460), and neuroticism (n = 170,911). We identify 3 variants associated with subjective well-being, 2 variants associated with depressive symptoms, and 11 variants associated with neuroticism, including 2 inversion polymorphisms. The two loci associated with depressive symptoms replicate in an independent depression sample. Joint analyses that exploit the high genetic correlation

SUBMITTER: Okbay A 

PROVIDER: S-EPMC4884152 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature