Centrosome associated genes pattern for risk sub-stratification in multiple myeloma.

ABSTRACT:

Background

The genome of multiple myeloma (MM) cells is extremely unstable, characterized by a complex combination of structure and numerical abnormalities. It seems that there are several "myeloma subgroups" which differ in expression profile, clinical manifestations, prognoses and treatment response. In our previous work, the list of 35 candidate genes with a known role in carcinogenesis and associated with centrosome structure/function was used as a display of molecular heterogeneity with an impact in myeloma pathogenesis. The current study was devoted to establish a risk stratification model based on the aforementioned candidate genes.

Methods

A total of 151 patients were included in this study. CD138+ cells were separated by magnetic-activated cell sorting (MACS). Gene

SUBMITTER: Kryukov F 

PROVIDER: S-EPMC4884414 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature