Genetic polymorphisms of pharmacogenomic VIP variants in the Mongol of Northwestern China.

ABSTRACT:

Background

Within a population, the differences of pharmacogenomic variant frequencies may produce diversities in drug efficacy, safety, and the risk associated with adverse drug reactions. With the development of pharmacogenomics, widespread genetic research on drug metabolism has been conducted on major populations, but less is known about minorities.

Results

In this study, we recruited 100 unrelated, healthy Mongol adults from Xinjiang and genotyped 85 VIP variants from the PharmGKB database. We compared our data with eleven populations listed in 1000 genomes project and HapMap database. We used χ(2) tests to identify significantly different loci between these populations. We downloaded SNP allele frequencies from the ALlele FREquency Database to observe the global geneti

SUBMITTER: Jin T 

PROVIDER: S-EPMC4884435 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature