Changes in Gene Expression and Hearing Thresholds After Cochlear Implantation.

ABSTRACT:

Hypothesis

Gene expression changes occur in conjunction with hearing threshold changes after cochlear implantation.

Background

Between 30 and 50% of individuals who receive electro-acoustic stimulation (EAS) cochlear implants lose residual hearing after cochlear implantation, reducing the benefits of EAS. The mechanism underlying this hearing loss is unknown; potential pathways include mechanical damage, inflammation, or tissue remodeling changes.

Methods

Guinea pigs were implanted in one ear with cochlear implant electrode arrays, with non-implanted ears serving as controls, and allowed to recover for 1, 3, 7, or 14 days. Hearing threshold changes were measured over time. Cochlear ribonucleic acid was analyzed using real-time quantitative reverse transcription-polyme

SUBMITTER: Zhang H 

PROVIDER: S-EPMC4884452 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature