ZYG11A serves as an oncogene in non-small cell lung cancer and influences CCNE1 expression.
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ABSTRACT:
SUBMITTER: Wang X
PROVIDER: S-EPMC4884973 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
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ZYG11A serves as an oncogene in non-small cell lung cancer and influences CCNE1 expression.
Wang Xin X Sun Qi Q Chen Chen C Yin Rong R Huang Xing X Wang Xuan X Shi Run R Xu Lin L Ren Binhui B
Oncotarget 20160201 7
By analyzing The Cancer Genome Atlas (TCGA) database, we identified ZYG11A as a potential oncogene. We determined the expression of ZYG11A in NSCLC tissues and explored its clinical significance. And also evaluated the effects of ZYG11A on NSCLC cell proliferation, migration, and invasion both in vitro and in vivo. Our results show that ZYG11A is hyper-expressed in NSCLC tissues compared to adjacent normal tissues, and increased expression of ZYG11A is associated with a poor prognosis (HR: 2.489 ...[more]
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