In Utero Tenofovir Exposure Is not Associated With Fetal Long Bone Growth.

ABSTRACT:

Background

Despite widespread use of tenofovir disoproxil fumarate (TDF) in pregnant and breastfeeding women, few data exist on fetal bone development after in utero TDF exposure. We evaluated fetal long bone growth in human immunodeficiency virus (HIV)-infected pregnant woman/fetus dyads in Cape Town, South Africa.

Methods

Women were recruited from primary care antenatal services and underwent ultrasonography to determine femur (FLZ) and humerus (HLZ) length z scores. The duration of in utero TDF exposure was calculated in weeks. Linear regression models were applied to assess the associations between the duration of in utero TDF exposure and change in FLZ and HLZ.

Results

A total of 646 woman/fetus dyads contributed 1376 ultrasonographic scans to this analysis: 132

SUBMITTER: Jao J 

PROVIDER: S-EPMC4885649 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature