Performance of magnetic resonance elastography in primary sclerosing cholangitis.

ABSTRACT:

Background and aim

Liver stiffness (LS) measured by magnetic resonance elastography (MRE) is emerging as an important biomarker in chronic liver diseases. We examined the diagnostic performance of MRE, factors associated with an increased LS and the prognostic value of LS as measured by MRE among patients with primary sclerosing cholangitis (PSC).

Methods

We performed a retrospective review of 266 patients with PSC to examine whether LS was associated with the primary endpoint of hepatic decompensation (ascites, variceal hemorrhage and hepatic encephalopathy). The ability of MRE to differentiate stages of fibrosis was examined in a subset of patients who underwent a liver biopsy (n = 20).

Results

An LS of 4.93 kPa was the optimal point to detected F4 fibrosis (sensiti

SUBMITTER: Eaton JE 

PROVIDER: S-EPMC4885758 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature