Safety of a short hydration method for cisplatin administration in comparison with a conventional method-a retrospective study.

ABSTRACT:

Objective

Cisplatin is administered in combination with massive hydration to avoid renal toxicity, making its administration difficult in an outpatient setting. Although a short hydration protocol for cisplatin has been recently developed, its safety is not fully understood.

Methods

Consecutive patients with lung or other cancer and an Eastern Cooperative Oncology Group performance status of 0-2 who were receiving chemotherapy containing cisplatin at a dose of ≥60 mg/m(2) in a single administration were evaluated. Seventy-four patients were treated with a short hydration protocol consisting of 1750-2250 ml of hydration with mannitol and magnesium supplementation over a period of 3.75-4.75 h on Day 1. Sixty-nine patients were treated with a conventional hydration protocol con

SUBMITTER: Sakaida E 

PROVIDER: S-EPMC4886127 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature