Targeting AMPK signaling in combating ovarian cancers: opportunities and challenges.

ABSTRACT: The development and strategic application of effective anticancer therapies have turned out to be one of the most critical approaches of managing human cancers. Nevertheless, drug resistance is the major obstacle for clinical management of these diseases especially ovarian cancer. In the past years, substantial studies have been carried out with the aim of exploring alternative therapeutic approaches to enhance efficacy of current chemotherapeutic regimes and reduce the side effects caused in order to produce significant advantages in overall survival and to improve patients' quality of life. Targeting cancer cell metabolism by the application of AMP-activated protein kinase (AMPK)-activating agents is believed to be one of the most plausible attempts. AMPK activators such as 5-aminoimidaz

SUBMITTER: Yung MM 

PROVIDER: S-EPMC4886241 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature