Impact of Fractionation and Dose in a Multivariate Model for Radiation-Induced Chest Wall Pain.

ABSTRACT:

Purpose

To determine the role of patient/tumor characteristics, radiation dose, and fractionation using the linear-quadratic (LQ) model to predict stereotactic body radiation therapy-induced grade ≥ 2 chest wall pain (CWP2) in a larger series and develop clinically useful constraints for patients treated with different fraction numbers.

Methods and materials

A total of 316 lung tumors in 295 patients were treated with stereotactic body radiation therapy in 3 to 5 fractions to 39 to 60 Gy. Absolute dose-absolute volume chest wall (CW) histograms were acquired. The raw dose-volume histograms (α/β = ∞ Gy) were converted via the LQ model to equivalent doses in 2-Gy fractions (normalized total dose, NTD) with α/β from 0 to 25 Gy in 0.1-Gy steps. The Cox proportional hazards (CPH)

SUBMITTER: Din SU 

PROVIDER: S-EPMC4886343 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature