Interferon-driven alterations of the host's amino acid metabolism in the pathogenesis of typhoid fever.

ABSTRACT: Enteric fever, caused by Salmonella enterica serovar Typhi, is an important public health problem in resource-limited settings and, despite decades of research, human responses to the infection are poorly understood. In 41 healthy adults experimentally infected with wild-type S. Typhi, we detected significant cytokine responses within 12 h of bacterial ingestion. These early responses did not correlate with subsequent clinical disease outcomes and likely indicate initial host-pathogen interactions in the gut mucosa. In participants developing enteric fever after oral infection, marked transcriptional and cytokine responses during acute disease reflected dominant type I/II interferon signatures, which were significantly associated with bacteremia. Using a murine and macrophage infection mod

SUBMITTER: Blohmke CJ 

PROVIDER: S-EPMC4886356 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature