Ontology highlight
ABSTRACT:
SUBMITTER: Lear T
PROVIDER: S-EPMC4886359 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
The Journal of experimental medicine 20160509 6
The E3 small ubiquitin-like modifier (SUMO) protein ligase protein inhibitor of activated STAT 4 (PIAS4) is a pivotal protein in regulating the TGFβ pathway. In this study, we discovered a new protein isoform encoded by KIAA0317, termed fibrosis-inducing E3 ligase 1 (FIEL1), which potently stimulates the TGFβ signaling pathway through the site-specific ubiquitination of PIAS4. FIEL1 targets PIAS4 using a double locking mechanism that is facilitated by the kinases PKCζ and GSK3β. Specifically, PK ...[more]