Computational recognition and analysis of hitherto uncharacterized nucleotide cyclase-like proteins in bacteria.

ABSTRACT:

Unlabelled

Evolutionary relationship between class III nucleotide cyclases and an uncharacterized set of bacterial proteins from Actinobacteria, Bacteroidetes and Proteobacteria has been recognized and analyzed. Detailed analyses of sequence and structural features resulted in the recognition of potential cyclase function conferring residues and presence of signature topological motif (βααββαβ) in the uncharacterized set of bacterial proteins. Lack of transmembrane domains and signal peptide cleavage sites is suggestive of their cytosolic subcellular localization. Furthermore, analysis on evolutionarily conserved gene clusters of the predicted nucleotide cyclase-like proteins and their evolutionary relationship with nucleotide cyclases suggest their participation in cellular signal

SUBMITTER: Ramakrishnan G 

PROVIDER: S-EPMC4886424 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature