Endothelial Activation Is Associated With Cognitive Performance in Patients With Hypertension.

ABSTRACT:

Background

Hypertension is associated with the occurrence of cognitive deficits and dementia, probably because hypertension is a major risk factor for the occurrence of brain damage as a result of cerebral small vessel disease (cSVD). Endothelial activation and inflammation have been suggested to play an important role in the pathogenesis of cSVD. We investigated if compound scores of endothelial activation or inflammation, based on several blood markers, are associated with cognitive performance 3 years later in patients with essential hypertension.

Methods

At baseline, levels of blood markers of endothelial activation (soluble vascular cellular adhesion molecule-1 (sVCAM-1), soluble intercellular adhesion molecule-1 (sICAM-1), sP-selectin, and sE-selectin) and markers of i

SUBMITTER: Uiterwijk R 

PROVIDER: S-EPMC4886483 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature