Critical Points in Tumorigenesis: A Carcinogen-Initiated Phase Transition Analyzed via Single-Cell Proteomics.
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ABSTRACT:
SUBMITTER: Poovathingal SK
PROVIDER: S-EPMC4886749 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Publications
Critical Points in Tumorigenesis: A Carcinogen-Initiated Phase Transition Analyzed via Single-Cell Proteomics.
Poovathingal Suresh Kumar SK Kravchenko-Balasha Nataly N Shin Young Shik YS Levine Raphael David RD Heath James R JR
Small (Weinheim an der Bergstrasse, Germany) 20160118 11
A kinetic, single-cell proteomic study of chemically induced carcinogenesis is interpreted by treating the single-cell data as fluctuations of an open system transitioning between different steady states. In analogy to a first-order transition, phase coexistence and the loss of degrees of freedom are observed. The transition is detected well before the appearance of the traditional biomarker of the carcinogenic transformation. ...[more]
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