Interaction Between Hippocampus and Cerebellum Crus I in Sequence-Based but not Place-Based Navigation.

ABSTRACT: To examine the cerebellar contribution to human spatial navigation we used functional magnetic resonance imaging and virtual reality. Our findings show that the sensory-motor requirements of navigation induce activity in cerebellar lobules and cortical areas known to be involved in the motor loop and vestibular processing. By contrast, cognitive aspects of navigation mainly induce activity in a different cerebellar lobule (VIIA Crus I). Our results demonstrate a functional link between cerebellum and hippocampus in humans and identify specific functional circuits linking lobule VIIA Crus I of the cerebellum to medial parietal, medial prefrontal, and hippocampal cortices in nonmotor aspects of navigation. They further suggest that Crus I belongs to 2 nonmotor loops, involved in different st

SUBMITTER: Igloi K 

PROVIDER: S-EPMC4886832 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature