The association analysis polymorphism of CDKAL1 and diabetic retinopathy in Chinese Han population.

ABSTRACT:

Aim

To identify the contribution of CDKAL1 to the development of diabetic retinopathy (DR) in Chinese population.

Methods

A case-control study was performed to investigate the genetic association between DR and polymorphic variants of CDKAL1 in Chinese Han population with type 2 diabetes mellitus (T2DM). A well-defined population with T2DM, consisting of 475 controls and 105 DR patients, was recruited. All subjects were genotyped for the genetic variant (rs10946398) of CDKAL1. Genotyping was performed by iPLEX technology. The association between rs10946398 and T2DM was assessed by univariate and multivariate logistic regression (MLR) analysis.

Results

There were significant differences in C allele frequencies of rs10946398 (CDKAL1) between control and DR groups (45.06

SUBMITTER: Liu NJ 

PROVIDER: S-EPMC4886891 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature