Computational Identification of Novel Stage-Specific Biomarkers in Colorectal Cancer Progression.

ABSTRACT: It is well-known that the conversion of normal colon epithelium to adenoma and then to carcinoma stems from acquired molecular changes in the genome. The genetic basis of colorectal cancer has been elucidated to a certain extent, and much remains to be known about the identity of specific cancer genes that are associated with the advancement of colorectal cancer from one stage to the next. Here in this study we attempted to identify novel cancer genes that could underlie the stage-specific progression and metastasis of colorectal cancer. We conducted a stage-based meta-analysis of the voluminous tumor genome-sequencing data and mined using multiple approaches for novel genes driving the progression to stage-II, stage-III and stage-IV colorectal cancer. The consensus of these driver genes s

SUBMITTER: Palaniappan A 

PROVIDER: S-EPMC4887059 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature