Natural history of cavernous malformation: Systematic review and meta-analysis of 25 studies.

ABSTRACT:

Objective

We pooled the results of studies on natural history of cavernous malformations (CM) to calculate point estimates and investigate main sources of heterogeneity.

Methods

We searched MEDLINE, EMBASE, and ISI Web of Science for relevant studies published before May 2015. We used fixed or random effects models and meta-regression to pool the data.

Results

Twenty-five studies were entered into the meta-analysis (90-1,295 patients depending on the analysis). Bleeding was defined as symptomatic hemorrhage plus radiologic evidence of hemorrhage. Sources of heterogeneity were identified as mixture of hemorrhage and rehemorrhage, mixture of rehemorrhage before and after 2 years of first bleeding, brainstem vs other locations, and calculation method. The rehemorrhage ra

SUBMITTER: Taslimi S 

PROVIDER: S-EPMC4887121 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature