Pathophysiologic differences in cerebral autoregulation after subarachnoid hemorrhage.

ABSTRACT:

Objective

To understand the physiologic basis of impaired cerebral autoregulation in subarachnoid hemorrhage (SAH) and its relationship to neurologic outcomes.

Methods

The cohort included 121 patients with nontraumatic SAH admitted to a neurointensive critical care unit from March 2010 to May 2015. Vasospasm was ascertained from digital subtraction angiography and delayed cerebral ischemia (DCI) was defined as new cerebral infarction on high-resolution CT. Cerebral blood flow and beat-by-beat pressure were recorded daily on days 2-4 after admission. Autoregulatory capacity was quantified from pressure flow relation via projection pursuit regression. The main outcome was early alterations in autoregulatory mechanisms as they relate to vasospasm and DCI.

Results

Forty-t

SUBMITTER: Santos GA 

PROVIDER: S-EPMC4887123 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature