Hyperactivation of JAK1 tyrosine kinase induces stepwise, progressive pruritic dermatitis.

ABSTRACT: Skin homeostasis is maintained by the continuous proliferation and differentiation of epidermal cells. The skin forms a strong but flexible barrier against microorganisms as well as physical and chemical insults; however, the physiological mechanisms that maintain this barrier are not fully understood. Here, we have described a mutant mouse that spontaneously develops pruritic dermatitis as the result of an initial defect in skin homeostasis that is followed by induction of a Th2-biased immune response. These mice harbor a mutation that results in a single aa substitution in the JAK1 tyrosine kinase that results in hyperactivation, thereby leading to skin serine protease overexpression and disruption of skin barrier function. Accordingly, treatment with an ointment to maintain normal skin

SUBMITTER: Yasuda T 

PROVIDER: S-EPMC4887165 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature