Clinical iron deficiency disturbs normal human responses to hypoxia.

ABSTRACT:

Background

Iron bioavailability has been identified as a factor that influences cellular hypoxia sensing, putatively via an action on the hypoxia-inducible factor (HIF) pathway. We therefore hypothesized that clinical iron deficiency would disturb integrated human responses to hypoxia.

Methods

We performed a prospective, controlled, observational study of the effects of iron status on hypoxic pulmonary hypertension. Individuals with absolute iron deficiency (ID) and an iron-replete (IR) control group were exposed to two 6-hour periods of isocapnic hypoxia. The second hypoxic exposure was preceded by i.v. infusion of iron. Pulmonary artery systolic pressure (PASP) was serially assessed with Doppler echocardiography.

Results

Thirteen ID individuals completed the study a

SUBMITTER: Frise MC 

PROVIDER: S-EPMC4887172 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature