Mild cognitive impairment in Parkinson's disease versus Alzheimer's disease.

ABSTRACT:

Introduction

No known studies have compared longitudinal characteristics between individuals with incident mild cognitive impairment due to Parkinson's disease (PD-MCI) versus Alzheimer's Disease (AD-MCI).

Methods

We used longitudinal data from the National Alzheimer's Coordinating Center's Uniform Data Set to compare 41 PD-MCI and 191 AD-MCI participants according to their demographics, presence of ≥1 APOE e4 allele, and baseline and change over time in clinical characteristics, neuropsychological test scores, and Clinical Dementia Rating sum of boxes (CDR-SB). Multivariable linear regression models with generalized estimating equations were used to account for clustered data and to test for baseline and longitudinal differences in neuropsychological test scores.

Results

SUBMITTER: Besser LM 

PROVIDER: S-EPMC4887313 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature